Temperature-controlled hand-foot cooling prevents chemotherapy-induced polyneuropathy (cipn): a real-world data collection in 500 patients

Advancements in oncology have significantly improved overall survival rates for cancer patients, particularly those with breast cancer. Consequently, the long-term side effects of chemotherapy—still a cornerstone of cancer treatment—on patients’ quality of life (QoL) are gaining increasing attention.Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of taxanes (paclitaxel, nab-paclitaxel, docetaxel). CIPN can significantly reduce QoL and may lead to dose delays, reductions, or even treatment discontinuation. Reported incidence rates of grade 2-3 CIPN reach up to 50% with three-weekly and up to 30% with weekly taxane-based regimens, which are frequently used in breast cancer treatment.Temperature-controlled hand-foot cooling (Hilotherapy®) has shown potential in preventing CIPN. At our oncology department, Hilotherapy® is an established component of supportive care. We present here the results of our real-world data collection on 500 breast cancer patients who received prophylactic Hilotherapy® during chemotherapy.

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