Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study

Patients and methods:
This was a single-center, randomized comparative observerblinded study comparing a 595-nm pulsed dye laser treatment and 1064-nm long pulsed Nd:YAG laser treatment in patients with angiokeratoma of Fordyce. Twenty-two patients with angiokeratoma of Fordyce were included in the present study, which was carried out within the period from July, 2013 to November 2014.

Comparisons between baseline and two months after the final treatment session by two independent dermatologists revealed clinically significant improvements in all treated areas by pulsed dye laser (61.80% ± 22.79 SD) and treated areas by Nd:YAG laser (77.63% ± 18.11 SD) where outcome was complete improvement (grade 6) in four patients on the side treated by long pulsed Nd:YAG laser and one patient only showed complete improvement on the side treated with PDL. There was a significant difference between both laser treatment with superior response with long pulsed Nd:YAG laser compared to Pulsed dye laser (p value50.05) (Table 2), which was evaluated clinically by two dermatologists according six grades of improvement (Figure 1).



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