Efficacy and safety of the combination of PRP + non-crosslinked hyaluronic acid versus hyaluronic acid, in mono-injection, in symptomatic knee osteoarthritis, randomized controlled phase in trial, single blind

Background: Despite the recent results of meta-analyses of randornized controlled trials (RCTs), the place of PRP and hyaluronic acid in the syrnptornatic treatment of knee osteoarthritis (KOA) remains uncertain in the latest international recommendations. Very few studies are available on the potential synergistic effect of their combination in mild to moderate forrns of KQA<11. Objectives: Randomized, controlled, multicenter, non-inferiority trial (clinical trial NCT03328728), single-blinded (investigator) to compare the efficacy and safety of the combination of PRP and non-crosslinked hyaluronic acid (PRP-HA, Cellular Matrix A-CP-HA, Regen Lab) as a single injection versus Hylan G-F 20 (HA), with follow-up at 1, 3 and 6 months, on an intention-to-treat (ITT) basis.